A decision-point between programmed cell death and transdifferentiation in pancreatic cancer

Mecanism of action of TAK inhibitor on immune cells and cancer cells extracted from pancreatic tumor (PDAC) Overall design: PDAC tumor tissue was processed and immune cells were isolated from other cell types that were grown as 3D tumorspheroids. Tumorspheroids were then treated with TAK inhibitor or DMSO as control. Conditionned media were harvested and used to stimulate immune cells. Immune cells were then analyzed by single cell RNA-Seq (SORT-Seq)