Polysubstituted Oxygen Heterocycles by a Reformatsky-Type Reaction/Reductive Cyclization Approach from Enantiopure β-Ketosulfoxides
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https://figshare.com/articles/dataset/Polysubstituted_Oxygen_Heterocycles_by_a_Reformatsky_Type_Reaction_Reductive_Cyclization_Approach_from_Enantiopure_Ketosulfoxides/2979001
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资源简介：
The stereoselective synthesis of tetrasubstituted tetrahydrofurans and trisubstituted tetrahydropyrans bearing a sulfoxide was achieved by
reductive cyclization (Et3SiH/TMSOTf) from the corresponding enantiopure hydroxy ketones protected as a dioxolane. These derivatives are
easily accessible from a Reformatsky-type reaction between α-bromo-α‘-sulfinyl ketones and protected α- or β-ketoaldehydes, followed by
diastereoselective reduction of the resulting β-ketosulfoxide.
创建时间：
2016-06-03
