Supplemental material, sj-sas-7-smm-10.1177_09622802211051089 for Allowing for stratification in sample size planning of two-arm trials with continuous or binary outcome: Overview and tutorial by Stef
Adaptive two-stage design with treatment selection, also called seamless Phase II/III design, has been recognized to save sample size and time to enhance the development of effective treatments. These
In this article, we consider randomized trial design to evaluate interventions with spatially or spatio-temporally heterogeneous effects. A common approach in this setting is the cluster randomized tr