EEG and histological measures from aging mice in the untreated/post-CS treated or prophylactically treated cohort.

Post-CS and prophylactic anticonvulsive treatments were conducted in two separate cohorts of aging mice (n = 24 and 21 respectively). Panel A: Changes in ipsilateral hippocampal EEG signals were analyzed in 8 and 5 animals with CS from these two cohorts respectively. Ipsilateral hippocampal EEG signals were normalized as a % of the baseline. The numbers of animals examined at different post-HI time points are indicated in the parentheses. Panel B: ipsilateral EEG signals were analyzed in untreated animals and prophylactically treated animals (n = 6 each) that did not exhibit CS and ipsilateral infarctions on later histological assessment. Data are similarly presented in Panel A. Panel C: The ratio of the ipsilateral to contralateral hemispheric areas measured in histological brain sections. These measurements were made in 4 untreated/post-CS treated animals and 7 prophylactically treated animals 4–5 weeks post-HI. There were no significant group differences in any EEG or histological measures (p>0.05, t test or Mann-Whitney Rank Sum Test).EEG and histological measures from aging mice in the untreated/post-CS treated or prophylactically treated cohort.