Late-Stage Functionalization of Aromatic Acids with Aliphatic Aziridines: Direct Approach to Form β‑Branched Arylethylamine Backbones
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https://figshare.com/articles/dataset/Late-Stage_Functionalization_of_Aromatic_Acids_with_Aliphatic_Aziridines_Direct_Approach_to_Form_Branched_Arylethylamine_Backbones/8340887
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资源简介：
A palladium-catalyzed
carboxylic acid-directed cross-coupling of
an ortho-C(sp2) atom of aromatic acids
with aliphatic aziridines to construct the β-arylethylamine
skeleton via C–H activation has been developed. The reaction
proceeded under mild conditions with great substrate scope. Meanwhile,
the β-arylethylamine skeleton in drugs or bioactive compounds
could be easily generated in a single step. A catalytic amount of
cesium carbonate was crucial to realizing the selective β-arylethylamine
synthesis.
创建时间：
2019-06-21
