Multinucleation resets human macrophages for specialized functions at the expense of their identity

To investigate the effects of macrophage cell fusion and multinucleation, we have sorted mononuclear and multinucleated macrophages from 3 types of polykaryons: osteoclasts, foreign body giant cells (FBGCs) and Langhans giant cells (LGCs). Comparative gene expression profiling by RNA-seq between mononuclear and multinucleated osteoclasts, FBGCs and LGCs