Transcriptome profiling of Propionibacterium freudenreichii strains associated with different anti-inflammatory properties.. Propionibacterium freudenreichii

Propionibacterium freudenreichii, a dairy starter, reaches a population close to 10^9 propionibacteria per gram of Swiss-type cheese at the time of consumption. Also consumed as a probiotic, it revealed strain-dependent anti-inflammatory properties mediated by proteins inducing IL-10 in leukocytes. Here, strains with varied anti-inflammatory potentials were compared in terms of transcriptome profiles. Overall design: Eight strains were analyzed in one growth condition. After visual quality check based on the distribution of probe intensities, most strains were represented by 2 biological replicates (1 biological replicate for one strain, and 3 biological replicates for two strains).