Crystal structure of selective IRE1a inhibitor 29 at the enzyme active site
收藏Protein Data Bank Japan2024-06-26 更新2026-04-19 收录
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Crystal structure of selective IRE1a inhibitor 29 at the enzyme active site Descriptor: 1,2-ETHANEDIOL, 1-phenyl-N-(2,3,6-trifluoro-4-{[(3M)-3-(2-{[(3R,5R)-5-fluoropiperidin-3-yl]amino}pyrimidin-4-yl)pyridin-2-yl]oxy}phenyl)methanesulfonamide, Serine/threonine-protein kinase/endoribonuclease IRE1 Authors: Kiefer, J.R, Wallweber, H.A, Braun, M.-G, Wei, W, Jiang, F, Wang, W, Rudolph, J, Ashkenazi, A. Deposit date: 2023-11-03 Release date: 2024-05-29 Last modified: 2024-06-26 Method: X-RAY DIFFRACTION (2.43 Å) Cite: Discovery of Potent, Selective, and Orally Available IRE1 alpha Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model. J.Med.Chem., 67, 2024
创建时间：
2023-11-03
