RORγt -expressing FOXP3+ skin-resident Treg cells derived from the periphery in Allergen-Specific Immunotherapy. RORγt -expressing FOXP3+ skin-resident Treg cells derived from the periphery in Allergen-Specific Immunotherapy

The study explored the impact of Specific Immunotherapy on patients with Atopic Dermatitis sensitized to house dust mites by analyzing the transcriptomes of T regulatory cells before and after treatment. Result found that effective SIT is associated with distinct gene expression changes in Treg cells, particularly increased expression of Treg markers and RORC, a gene linked to immune regulation. These results indicate that successful SIT may enhance the function of Treg cells expressed RORC and help restore immune balance in these patients. Overall design: Patients with Atopic Dermatitis (AD) sensitized to house dust mites are divided into two groups based on their response to Specific Immunotherapy (SIT): those who showed an effective response (R) and those who did not respond (Non-R). Results identified differentially expressed genes before and after SIT in R and Non-R groups.