Additional file 1 of Sex differences in the polygenic architecture of hearing problems in adults

Additional file 1: Table S1. Definition of the combined four-category ordinal phenotype based on the traits defined in the UKB. Binary definitionswere combined to define a severity/probability scalAQe of hearing problems. Table S2. Environments investigated in the GEWIS analysis. Table S3. Inflation statistics of hearing problem genome-wide association studies. Table S4. Genetic correlations among the HP traits assessed in UKB considering sex-combined and and sex-stratified analyses. rg: genetic correlation; se: standard error. Table S5. Effect size comparison between sex-specific findings in the meta-analyses. Results surviving multiple testing correction are highlighted in red. GWS:genome-wide significance in; REF: reference allele; ALT: alternative allele; A1:Effect allele; SE:standard error. Table S6. Association of the hearing-problem polygenic risk score derived from the UKB-NHS-HPFS sex-combined meta-analysis in the MVP cohort. Table S7. Association of the hearing-problem polygenic risk score derived from the UKB-only sex-combined GWAS in the NHS-HPFS combined sample. Table S8. Association of the hearing-problem polygenic risk score derived from the UKB-only female-specific GWAS in the NHS sample. Table S9. Association of the hearing-problem polygenic risk score derived from the UKB-only male-specific GWAS in the HPFS sample. Table S10. Single-variant replication in other ancestry groups available in UKB. REF: reference allele; ALT: alternative allele; se:standard error; pval:P; af:allele frequency. FDR significantand nominally significant replications are highlighted in yellow and red, respectively. Table S11. Association of the hearing-problem polygenic risk score derived from the UKB-NHS-HPFS sex-combined meta-analysis in the UKB AFR sample. Table S12. Association of the hearing-problem polygenic risk score derived from the UKB-NHS-HPFS sex-combined meta-analysis in the UKB AMR sample. Table S13. Association of the hearing-problem polygenic risk score derived from the UKB-NHS-HPFS sex-combined meta-analysis in the UKB CSA sample. Table S14. Association of the hearing-problem polygenic risk score derived from the UKB-NHS-HPFS sex-combined meta-analysis in the UKB EAS sample. Table S15. Prioritized genes considering a CADD score threshold of 10. MAF:Minor allele frequency; se: standard error. Table S16. HP-associated genesin the Multi-tissue TWAS using S-MultiXcan. Table S17. Multi-tissue TWS associations after Bonferroni multiple testing correction identified in the sex-stratified analyses. Table S18. Enrichment for specific genomic features with respect to sex-combined and sex-stratified analyses. Results surviving Bonferroni multiple testing correction are highlighted in yellow. Table S19. Phenome-wide genetic correlation with HP considering sex-combined GWAS. Results surviving multiple testing correction are highlgihted in red rg: genetic correlation; se:standard error. Table S20. LCV analysis for HP. Results surviving Bonferroni multiple testing correction are indicated in red. gcp p: p-value for the genetic causality proportion; gcp: posterior genetic causality proportion; gcp se: standard error for the genetic causality proportion estimate; rho.est: genetic correlation estimate from LCV; rho.err: standard error for genetic correlation estimate from LCV. Table S21. Environment-specific Bayes factors of the LD-independent variants with nominally significant multi-environment interactions.