Expansion of UBTR012574 Chemical Series
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Expansion of the chemical series of UBTR012574 (K<sub>D</sub>= 10 ± 0.1 µM) by docking analogue compounds from the Enamine REAL database and SciFinder against the USP5 zinc finger ubiquitin-binding domain (ZnF-UBD) to prioritize compound ordering. The binding potency of the ordered compounds against USP5 ZnF-UBD was assessed with a surface plasmon resonance (SPR) assay.
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2020-03-09
