Consequences of the perivascular niche remodeling for tumoricidal T-cell trafficking into metastasis of ovarian cancer [Spatial Transciptomics]

We investigated the mechanisms by which inflammatory responses generated by tumor-specific T cells delivered to ovarian tumor-bearing mice alone or after oncolytic vaccinia virus-driven immunogenic cancer cell death affect antitumor efficacy using spatial transcriptomics. Changes in the perivascular tumor microenvironment within the ovarian cancer metastasis in MOVCAR 5009 tumor-bearing SCID mice were analyzed by Spatial Transcriptomic analysis using 10x Genomic Visium platform 10 days after the treatment.