Regioselective Synthesis of Sulfonyl-Containing Benzyl Dithiocarbamates through Copper-Catalyzed Thiosulfonylation of Styrenes

An
efficient approach for the preparation of sulfonyl-containing
benzyl dithiocarbamates has been developed using tetraalkylthiuram
disulfides as the thiolating agents and sulfonyl chlorides as the
sulfonyl sources in the presence of the copper catalyst. The dithiocarbamate
group together with the sulfonyl group was simultaneously introduced
into styrene in chemo- and regioselective manners. This protocol provides
a convenient procedure, with good yields and functional group tolerance
to various important sulfonyl-containing benzyl dithiocarbamates.