SHISA 1601 data

Background Venous thromboembolism (VTE) is a potentially fatal perioperative complication. This study aimed to clarify the frequency and risk factors of intercurrent venous thromboembolism (VTE) in patients undergoing major curative gastric cancer surgery.
Methods This prospective multicenter observational study included patients with gastric cancer who underwent radical gastrectomy at 5 hospitals between June 2016 and May 2018. Patients who were preoperatively administered anticoagulants were excluded.
Results A total of 126 patients were eligible to participate. VTE occurred within 9 days postoperatively in 5 cases (4.0 %; 2 symptomatic and 3 asymptomatic). Postoperative day (POD) 1 plasma D-dimer and soluble fibrin (SF) levels were significantly higher in the VTE group than in the non-VTE group. Receiver operating characteristic curve analysis indicated a statistically significant ability of POD 1 D-dimer and SF levels to predict postoperative VTE development after gastrectomy; this finding was reflected by areas under the curve of 0.97 (95% confidence interval [CI], 0.92–1.0) and 0.87 (95% CI, 0.74–1.0). Cutoff values of D-dimer (24.6 µg/mL) and SF (64.1 µg/mL) were determined. Intraoperative blood transfusion (odds ratio [OR], 7.86), POD 1 D-dimer ≥24.6 µg/mL (OR, 17.35), and POD 1 SF ≥64.1 µg/mL (OR, 19.5) were independent risk factors for postoperative VTE (p < 0.05).
Conclusion VTE occurred in 4.0% patients after gastric cancer surgery; however, with an early diagnosis and anticoagulant therapy, no patients experienced progression. Careful observation of patients with high risk factors for VTE, including intraoperative blood transfusion and high POD 1 D-dimer or SF levels, would contribute to the early detection of VTE.