Transcription factor EHF interacting with transcription coactivator AJUBA (JUB) aggravates malignancy of gastroesophageal adenocarcinoma [ATAC-seq]

Transcriptional dysregulation of genes is a hallmark of tumors and can be pharmacologically developed in cancer. However, little is known about the interaction or transcriptional cooperativity between TF and transcription cofactor in gastroesophageal adenocarcinoma (GEA). Overall design: The molecular mechanism was mainly through RNA-seq, ChIP-seq, ATAC-seq, co-IP and MS.