BindingDB Entry 50044593: Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases.

Small molecule binding data for protein 40S ribosomal protein S27, AKT/p21CIP1, ALK tyrosine kinase receptor, Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase, Aurora kinase B/Inner centromere protein, CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase), Cyclin-dependent kinase 2, Cytochrome P450 2C9, Cytochrome P450 2D6 (2D6), Cytochrome P450 3A, Ephrin receptor, Epidermal growth factor receptor, Fibroblast growth factor receptor 1, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, High affinity immunoglobulin gamma Fc receptor I, Inhibitor of NF-kappa-B kinase (IKK), Insulin receptor, JAK2/TYK2, JAK3/JAK1, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, MAP kinase ERK2, MAP kinase signal-integrating kinase 2, MAP kinase-activated protein kinase 2, Maternal embryonic leucine zipper kinase (MELK), Mitogen-activated protein kinase 14, Mitotic checkpoint serine/threonine-protein kinase BUB1, Neurotrophic tyrosine kinase receptor, PKC alpha and beta-2, Pancreatic endoplasmic reticulum kinase (PERK), Proto-oncogene tyrosine-protein kinase ROS, Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1), SRC, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase EEF2K, Serine/threonine-protein kinase MST4, Serine/threonine-protein kinase NEK6, Serine/threonine-protein kinase NIM1, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase haspin, Tyrosine kinase non-receptor protein 2, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BRK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase Kit (Kit), Tyrosine-protein kinase SYK, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor FLT3, and Vascular endothelial growth factor receptor 2, Uniprot O00311, O00418, O14757, O14920, O14965, O43683, O60674, O96013, P00519, P00533, P04629, P05771, P06213, P06239, P07948, P07949, P08581, P08684, P08922, P10635, P10721, P11309, P11362, P11712, P12314, P23458, P24941, P28482, P29317, P29597, P31749, P35916, P35968, P36888, P42677, P43403, P43405, P49137, P49841, P52333, P53350, Q05397, Q07912, Q13882, Q14680, Q15118, Q16539, Q86V86, Q8IY84, Q8TF76, Q96GD4, Q9HBH9, Q9HC98, Q9NZJ5, Q9P1W9, Q9P289, Q9UBU7, and Q9UM73