Description of data and code for Williams et al "Spatial modulation of dark versus bright stimulus responses in the mouse visual system," Current Biology, 2021

<br>This data archive contains all code and data necessary to replicate each main text and supplementary figure and associated statistical comparisons in the following article:<br>Williams, B., Del Rosario, J., Muzzu, T., Peelman, K., Coletta, S., bichler, E. K., Speed, A., Meyer-Baese, L., Saleem, A. B. &amp; Haider, B. (2021). Spatial modulation of dark versus bright stimulus responses in the mouse visual system. Current Biology, 31, 1-8. <br>The data and code is compatible with Matlab 2018 or later.<br>The data archive is organized as self-contained subfolders corresponding to the results found in each main figure (e.g., folder 'F1' for results of Figure 1). Each subfolder contains code that loads the minimally processed data structures for replication of the published figures.<br>Abstract of associated publication: <br>A fundamental task of the visual system is to respond to both increases and decreases of luminance with action potentials (ON and OFF responses). OFF responses are stronger, faster, and more salient than ON responses in primary visual cortex (V1) of both cats and primates, but in ferrets and mice ON responses can be stronger, weaker, or balanced in comparison to OFF responses. These discrepancies could arise from differences in species, experimental techniques, or stimulus properties, particularly retinotopic location in the visual field, as has been speculated; however, the role of retinotopy for ON/OFF dominance has not been systematically tested across multiple scales of neural activity within species. Here, we measured OFF versus ON responses across large portions of visual space with silicon probe and whole-cell patch-clamp recordings in mouse V1 and lateral geniculate nucleus (LGN). We found that OFF responses dominated in the central visual field, whereas ON and OFF responses were more balanced in the periphery. These findings were consistent across local field potential (LFP), spikes, and subthreshold membrane potential in V1, and were aligned with spatial biases in ON and OFF responses in LGN. Our findings reveal that retinotopy may provide a common organizing principle for spatial modulation of OFF versus ON processing in mammalian visual systems. <br>Code repository can be found at https://doi.org/10.6084/m9.figshare.14872143<br>Post created on '02-Jul-2021 17:46:34'<br>