Table S1 - Integrity of p53 Associated Pathways Determines Induction of Apoptosis of Tumor Cells Resistant to Aurora-A Kinase Inhibitors

Ionizing radiation mimetic neocarzinostatin induces apoptosis of HCT116 Chk2(-) and MK-8745-resistant HCT116 Chk2(-) cells. HCT116 isogenic variants (Puma(-), Bax(-), p53(-), p21(-) and Chk2(-) cells) and their Aurora-A inhibitor-resistant variants recovered from xenograft (Figure 3) were further treated with neocarzinostatin (0.5 µg/ml, 12 h), and cell cycle profile was determined by at least two independent FACS analysis.
(DOCX)