Synthesis and Cytotoxicity Evaluation of a Series of 3-Alkenyl-2-Hydroxy-1,4-Naphthoquinones Obtained by an Efficient Knoevenagel Condensation
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https://scielo.figshare.com/articles/Synthesis_and_Cytotoxicity_Evaluation_of_a_Series_of_3-Alkenyl-2-Hydroxy-1_4-Naphthoquinones_Obtained_by_an_Efficient_Knoevenagel_Condensation/7591373
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A modified and efficient Knoevenagel condensation procedure was developed to synthesize the title compounds using β-alanine and acetic acid as catalysts, showing good to excellent yields. We used lawsone with suitable aliphatic aldehydes including isobutyraldehyde, 3-methyl-butyraldehyde, 2-ethylbutyraldehyde, phenylacetaldehyde, 2-phenyl-propionaldehyde, among others. These compounds were submitted to cytotoxic screening against three tumor cell lines presenting good to excellent cytotoxic profiles.
提供机构：
SciELO journals
创建时间：
2019-01-16
