AKT1 E17K mutant is phosphorylated by TORC2 complex
收藏reactome.org2025-01-16 收录
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PIP2-binding AKT1 E17K mutants are anchored to the plasma membrane in the absence of PI3K activity and are constitutively phosphorylated on serine S473, presumably by the TORC2 complex (Carpten et al. 2007, Landgraf et al. 2008).
PI3K活性缺失时,PIP2结合的AKT1 E17K突变体锚定于质膜,并在丝氨酸S473上持续磷酸化,推测由TORC2复合体介导(Carpten等,2007年,Landgraf等,2008年)。
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