Enteric Nervous System Derived IL-18 Orchestrates Mucosal Barrier Immunity. Enteric Nervous System Derived IL-18 Orchestrates Mucosal Barrier Immunity

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series. Key for bulk RNA sequencing samples: Hand2 Experiment: WT_PRX_5 = IL18f/f Hand2Cre- Prox Colon 1, WT_PRX_6 = IL18f/f Hand2Cre- Prox Colon 2, KO_PRX_7 = IL18f/f Hand2Cre+ Prox Colon 1, KO_PRX_8 = IL18f/f Hand2Cre+ Prox Colon 2. Villin Experiment: V1 = IL18f/f Vil1Cre- Prox Colon 1, V3 = IL18f/f Vil1Cre- Prox Colon 2, V2 = IL18f/f Vil1Cre+ Prox Colon 1, V4 = IL18f/f Vil1Cre+ Prox Colon 2. Flk Experiment: F5 = IL18f/f FlkCre- Prox Colon 1, F6 = IL18f/f FlkCre- Prox Colon 2, F7 = IL18f/f FlkCre+ Prox Colon 1, F8 = IL18f/f FlkCre+ Prox Colon 2 Key for single cell sequencing data from littermate steady state animals: Sample_5 = Il18f/f (n=2 combined), Sample_6 = Il18f/f Hand2Cre+ (n=2 combined).