Response of ancestral and mutant receptors to 11-deoxycorticosterone (DOC).
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aAll mutations were introduced into the AncCR background; AncGR1.1 is shown for comparison. Mutations are listed in order of the magnitude of their effect.bThe log effective concentration of hormone for half-maximal activation plus standard error, calculated from nonlinear regression of triplicate reactions in a reporter gene assay.cFold change in EC50 indicates the ratio of EC50 of the listed receptor to the EC50 of AncCR, both for deoxycorticosterone. Positive values indicate reduced sensitivity.
创建时间:
2015-12-02



