Metal−Organic Frameworks as Efficient Oral Detoxifying Agents

Poisoning and accidental oral intoxication are<br> major health problems worldwide. Considering the insufficient<br> efficacy of the currently available detoxification treatments, a<br> pioneering oral detoxifying adsorbent agent based on a single<br> biocompatible metal−organic framework (MOF) is here<br> proposed for the efficient decontamination of drugs commonly<br> implicated in accidental or voluntary poisoning. Furthermore, the<br> in vivo toxicity and biodistribution of a MOF via oral<br> administration have been investigated for the first time. Orally<br> administered upon a salicylate overdose, this MOF is able to<br> reduce the salicylate gastrointestinal absorption and toxicity more<br> than 40-fold (avoiding histological damage) while exhibiting exceptional gastrointestinal stability (&lt;9% degradation), poor<br> intestinal permeation, and safety.