BindingDB Entry 50003034: Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model.

Small molecule binding data for protein Aurora kinase B, Discoidin domain-containing receptor 2, Ephrin receptor, Ephrin type-A receptor 2, Ephrin type-A receptor 7, Epithelial discoidin domain-containing receptor 1, Eukaryotic translation initiation factor 2-alpha kinase 1, Fibroblast growth factor receptor 1, Focal adhesion kinase 1, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Hepatocyte growth factor receptor, High affinity nerve growth factor receptor, Interferon-induced, double-stranded RNA-activated protein kinase, Mast/stem cell growth factor receptor Kit, Mitogen-activated protein kinase kinase kinase 10, Mitogen-activated protein kinase kinase kinase 2, Mitogen-activated protein kinase kinase kinase 9, Mitogen-activated protein kinase kinase kinase kinase 2, Mitogen-activated protein kinase kinase kinase kinase 3, Mitogen-activated protein kinase kinase kinase kinase 5, Mixed lineage kinase 7, Neurotrophic tyrosine kinase receptor, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene tyrosine-protein kinase receptor Ret, Receptor-interacting protein 1 (RIPK1), Receptor-interacting serine/threonine-protein kinase 3, Receptor-interacting serine/threonine-protein kinase 4, SRC, Serine/threonine-protein kinase MST2, Serine/threonine-protein kinase NEK2, Serine/threonine-protein kinase RIPK2, Serine/threonine-protein kinase WNK3, Tyrosine kinase non-receptor protein 2, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase ABL2, Tyrosine-protein kinase BRK, Tyrosine-protein kinase BTK, Tyrosine-protein kinase Blk, Tyrosine-protein kinase Fgr, Tyrosine-protein kinase Fyn, Tyrosine-protein kinase HCK, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase Lyn, Tyrosine-protein kinase Mer, Tyrosine-protein kinase Yes, Tyrosine-protein kinase receptor UFO, Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), and p38 delta/gamma, Uniprot A0A024QZA8, A0A024QZU0, A0A024QZU1, A0A024R567, A0A024R759, A0A024R7T2, A0A024R8E2, A0A024R906, A0A024RAH0, A0A024RCL1, A0A024RD04, A0A0S2Z3Y8, A0A0S2Z4Z8, A0A384MR07, L7RSL3, O15264, O43353, P00519, P04629, P06239, P06241, P07947, P07948, P07949, P08581, P08631, P09769, P10721, P11362, P12931, P17948, P19525, P29317, P29322, P30530, P35916, P42684, P51451, P51955, P57078, P80192, Q02763, Q02779, Q05397, Q06187, Q07912, Q08345, Q08881, Q12851, Q12866, Q13188, Q13546, Q13882, Q15375, Q16288, Q16620, Q16832, Q548C2, Q8IVH8, Q96GD4, Q9BQI3, Q9BYP7, Q9NYL2, Q9Y2U5, Q9Y4K4, Q9Y572, and X5D2R1