Supplementary materials: Off-label antipsychotic use patterns among Texas Medicaid adults 2013–2016

This is a peer-reviewed supplementary table for the article 'Off-label antipsychotic use patterns among Texas Medicaid adults 2013–2016' published in the Journal of Comparative Effectiveness Research.Supplementary Table 1: Diagnosis and ICD-9-CM, ICD-10-CM CodesSummary: Aim: To describe trends in off-label antipsychotic use among Texas Medicaid adults and examine whether demographic and clinical characteristics were associated with off-label use. Methods: Three diagnostic groups (i.e. no diagnosis, on label and off-label) were created based on mental health disorder diagnoses and related antipsychotic prescriptions. Results: During 2013–2016, the prevalence of off-label antipsychotic use decreased from 22.5% to 17.4% and the proportions of no mental health diagnosis remained stable (7.3–9.4%). Patients aged ≥25 years and second-generation antipsychotic users had significantly lower odds of receiving antipsychotics off-label or with no diagnosis. Conclusion: Compared with previous Medicaid database studies, the proportions of off-label antipsychotic use and antipsychotic use with no concurrent psychiatric diagnosis were notably lower.

本表为发表于《比较疗效研究杂志》的论文《2013-2016年德克萨斯州医疗补助计划成年人非标签抗精神病药物使用模式》的同行评审补充表格。补充表1：诊断及ICD-9-CM、ICD-10-CM编码概要：目标：描述德克萨斯州医疗补助计划成年人非标签抗精神病药物使用趋势，并探讨人口统计学和临床特征是否与非标签使用相关。方法：根据精神健康障碍诊断和相关抗精神病药物处方，创建了三个诊断组（即无诊断、标签内和标签外）。结果：在2013-2016年间，非标签抗精神病药物的使用率从22.5%下降至17.4%，无精神健康诊断的比例保持稳定（7.3%-9.4%）。年龄≥25岁且使用第二代抗精神病药物的患者的非标签或无诊断接受抗精神病药物的可能性显著降低。结论：与之前的医疗补助数据库研究相比，非标签抗精神病药物的使用比例以及无并发精神疾病诊断的抗精神病药物使用比例均显著降低。