Hazard ratios (95% confidence intervals) for incident chronic kidney disease by serum bilirubin quartiles among subjects who did not have any evidence of liver disease (N = 10,348).

Model 1: Adjusted for age, smoking, alcohol intake and exercise.Model 2: Further adjusted for eGFR, CRP, AST, ALT, GGT and metabolic syndrome traits (high glucose, high blood pressure, low HDL cholesterol, high triglycerides and high BMI). *estimated from pooled logistic regression models with serum bilirubin quartiles as time-dependent categorical variable s adjusted for other covariates (age, smoking, alcohol intake, exercise, eGFR, CRP, AST, ALT, GGT and each metabolic syndrome trait) over time as time-dependent variables.Abbreviations: CI, confidence interval; eGFR: estimated glomerular filtration rate; HDL, high-density lipoprotein; HR, hazard ratio; LDL, low-density lipoprotein; ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma-glutamyltransferase.