Transcriptomes in Human neuroblastoma cell line SH-SY5Y under oxidative stress conditions

The SH-SY5Y Human neuroblastoma cell line was subcloned from the SK-N-SH cell line, which has been isolated from a bone marrow biopsy of a 4 year-old female patient. To examine the overall distribution of gene expression under stress condition in human neuronal cells, we investigated changes in the transcriptome profiles in the SH-SY5Y cells exposed with sodium arsenite which causes oxidative stress. We detected changes in the expression levels for several genes including FOS and Jun, which are well-known stress-dependent upregulated genes.