Brain lesions associated with communication-related quality of life following surgical removal of primary left-hemisphere tumors

This study aimed to (1) comprehensively characterize health-related quality-of-life (QOL) in individuals 6-24 months following surgical resection of left-hemisphere tumors and (2) examine the relationships between QOL and neuroanatomical characteristics of the lesion in the same cohort. Specifically, QOL measures were selected to capture communication, mood (depression, anxiety, and stress), and living with brain tumors. The lesions were evaluated based on the primary surgical resection, the resection plus brain damage and residual tumor/reoccurrence, and residual characteristics only. The relationships between QOL and the lesions were quantified using voxel-wise LSM and white-matter-tract disconnection severity analyses.

本研究旨在（1）全面描述在左侧半球肿瘤手术切除后6至24个月内的个体与健康相关生活质量（QOL）的特点；（2）探究生活质量与同批次个体病变神经解剖特征之间的关系。具体而言，选取了生活质量测量指标以捕捉沟通、情绪（抑郁、焦虑和压力）以及与脑肿瘤共处的情况。病变的评估基于主要手术切除、切除加脑损伤及残留肿瘤/复发，以及仅残留特征。通过体素层面的LSM和白质束断连严重程度分析，量化了生活质量与病变之间的关系。