Transcriptome analysis in acute GI GVHD reveals a unique signature in children and shared biology with pediatric IBD

We demonstrate a unique gene signature in acute GI GVHD with differential expression of genes which have been previously described as important in GVHD Overall design: We performed transcriptomic analyses on freshly frozen (n=21) and paraffin embedded (n=35) gastrointestinal (GI)biopsies from children with and without acute GI graft versus host disease (GVHD) to study differential gene expressions