The structure of a stable intermediate in the A ↔ B DNA helix transition
收藏PubMed Central2000-02-25 更新2026-04-25 收录
下载链接：
https://pmc.ncbi.nlm.nih.gov/articles/PMC15749/
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资源简介：
The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 Å has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A ↔ B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein–DNA recognition.
提供机构：
National Academy of Sciences
创建时间：
2000-02-25
