Generation of human excitatory forebrain neurons by cooperative binding of proneural NGN2 and homeobox factor EMX1

We explored NGN2’s molecular chromatin function and its ability to induce specific neuronal programs in the context of different cell states and different transcription factor combinations using a series of single cell and bulk genomic sequencing techniques and epigenomic methods. Examining the effect of chromatin and cofactor expression in Ngn2 binding and outcomes