STAT3 binds TSLP:IL7R:CRLF2
收藏reactome.org2025-01-16 收录
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Inferred from mouse:
The receptor for Thymic stromal lymphopoietin (TSLP) consists of Cytokine receptor-like factor 2 (CRLF2, TSLPR) and Interleukin-7 receptor subunit alpha (IL7R). Ba/F3cells expressing human IL7R or human TSLPR, or both stimulated with TSLP induce phosphorylation of Signal transducer and activator of transcription 3 (STAT3) and Signal transducer and activator of transcription 5A or B (STAT5A, STAT5B or STAT5), only in cells expressing both receptors (Reche et al.2001).
This is a black box event since there is no experimental details confirming binding of STAT3 and STAT5 to the receptor complex.
该数据集源于小鼠，揭示了Thymic stromal lymphopoietin (TSLP) 受体由Cytokine receptor-like factor 2 (CRLF2, TSLPR) 及Interleukin-7 receptor subunit alpha (IL7R) 组成。在Ba/F3细胞中，若表达人类IL7R或人类TSLPR，或两者兼而有之，经TSLP刺激后，仅能在同时表达两种受体的细胞中诱导Signal transducer and activator of transcription 3 (STAT3) 及Signal transducer and activator of transcription 5A或B (STAT5A, STAT5B 或 STAT5) 的磷酸化（Reche等，2001年）。此过程属于黑箱事件，因为缺乏实验细节证实STAT3和STAT5与受体复合物的结合。
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