Discovery of an orally bioavailable reversible covalent SARS-CoV-2 Mpro inhibitor with pan-coronavirus activity
收藏Protein Data Bank Japan2025-09-10 更新2026-03-21 收录
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Discovery of an orally bioavailable reversible covalent SARS-CoV-2 Mpro inhibitor with pan-coronavirus activity Descriptor: (S)-2-((R)-2-cyclopentyl-2-pivalamidoacetamido)-N-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-4-oxo-1-((S)-2-oxopiperidin-3-yl)butan-2-yl)pentanamide, 3C-like proteinase nsp5, cyclopropylcarbamic acid Authors: Baburajendran, N. Deposit date: 2024-11-08 Release date: 2025-08-20 Last modified: 2025-09-10 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Discovery of an Orally Bioavailable Reversible Covalent SARS-CoV-2 M pro Inhibitor with Pan-Coronavirus Activity. J.Med.Chem., 68, 2025
创建时间：
2024-11-08
