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Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte proliferation and heart repair after myocardial infarction [ChIP-Seq]

Alliance of Genome Resources2026-08-01 收录

心肌细胞增殖

心脏修复

数据链接：

https://www.ncbi.nlm.nih.gov/gds/?term=GSE202168 数据链接链接失效反馈

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资源简介：

To explore effect of DYRK1A silencing on H3K4me3 and H3K27ac modification of primary cultured cardiomyocytes isolated from 1-day-old SD rats

应用场景：

心肌细胞增殖

信号通路

BackgroundâYAP, the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEAD sequence specific DNA-binding protei

NIAID Data Ecosystem80

Interaction of YAP1 with the Myb-MuvB (MMB) complex sustain proliferation in the postnatal heart

心肌细胞增殖

发育分子机制

YAP, a major downstream effector of the Hippo signaling pathway, is an important regulator of cell proliferation. Previous studies have shown that YAP cooperates with the two transcription factors E2F

NIAID Data Ecosystem40

YAP promotes cardiomyocyte cell cycle entry. YAP promotes cardiomyocyte cell cycle entry

器官再生医学

心肌细胞增殖

Specialized adult somatic cells, such as cardiomyocytes (CMs), are highly differentiated with poor renewal capacity, an integral reason underlying organ failure in disease and aging. Among the least r

NIAID Data Ecosystem30

Screening in Human Cardiac Organoids Identifies a Requirement for the Mevalonate Pathway in Cardiomyocyte Proliferation. Screening in Human Cardiac Organoids Identifies a Requirement for the Mevalonate Pathway in Cardiomyocyte Proliferation

器官再生医学

心肌细胞增殖

Purpose: Induction of endogenous proliferation is a promising strategy for cardiac regeneration. We find that GSK3 inhibition activates a cell cycle network whereas MST1 inhibition drives the mevalona

NIAID Data Ecosystem50

Single cell RNA-seq of postnatal mouse cardiomyocytes

单细胞RNA测序

心肌细胞增殖

Understanding the regulatory mechanism by which mammalian cardiomyocyte proliferationtransitions to endoreplication and cell cycle arrest during the neonatal period is crucial for identifying pro-prol

NIAID Data Ecosystem40

Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte proliferation and heart repair after myocardial infarction [ChIP-Seq]

资源简介：

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