Specific types of male infertility are correlated with T cell exhaustion or senescence signatures

Infertility affects almost 15–20% of couples of reproductive age in Western countries, and a pure male factor is responsible for about half of these cases. Despite infertile men show a poorer general health status compared to age-matched fertile men, a comprehensive understanding of the association between infertility and the overall impoverishment of men's health was still lacking.
In the manuscript “Specific types of male infertility are correlated with T cell exhaustion or senescence signatures" (doi.org/10.1038/s41467-025-56193-2), we investigated the immune system of primary infertile men. We showed that both the semen and blood of these subjects exhibit a pro-inflammatory status resembling the one found in elderly men, suggesting that infertility could be linked to early aging of the immune system.
The datasets loaded contain all the clinical and immunological data supporting our conclusions and that have been used to build the main and supplementary figures/tables of the manuscript. An additional file (raw_data_description) contains the main guidelines to correctly associate the raw data with the corresponding figure/table in the manuscript.