Gene expression data from mouse melanocyte cell lines established in culture from 3-day old skin of wild-type and bcat* mutant C57BL/6J mice. Gene expression data from mouse melanocyte cell lines established in culture from 3-day old skin of wild-type and bcat* mutant C57BL/6J mice

To investigate the mechanism underlying the altered localization of pigmented melanosomes in cells expressing activated beta-catenin, we extracted mRNA from WT and bcat* cell lines and performed microarray-based transcriptome analysis. Overall design: We previously studied the effect of beta-catenin on the melanocyte lineage by creating a transgenic mouse model containing a stable, transcriptionally active beta-catenin mutant protein specifically in the melanocyte lineage (bcat* mice; Delmas et al., Genes Dev 2007). Melanocytes from the skin of wild-type C57BL/6J and bcat* mice were isolated and different cell lines were established in culture. In this study, we performed Affymetrix transcription microarray experiments on two wild-type (9v and 14d) and two bcat* (10d and 13d) cell lines.