AdhereTech Device Tracking in Triggered Escalating Real-time Adherence Intervention to Promote Rapid HIV Viral Suppression among Youth Living with HIV Failing Antiretroviral Therapy: The TERA Study

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Study Description
ATN 152 TERA was a multi-site two-arm RCT comparing HIV-1 RNA viral suppression and electronic dose monitored (EDM) ART adherence in youth living with HIV with detectable viral load assigned to receive either the TERA intervention or standard of care for HIV. Participants assigned to the 12-week intervention condition received 3 remote coaching sessions through video enabled conferencing and interacted via text and phone in real-time for any delayed or missed doses signaled by the participant’s EDM. The intervention was evaluated on viral suppression at week 12 and participants were followed through to week 48. Viral suppression and adherence, as well as psychosocial functioning, across the 48 weeks were also examined. The intervention did not improve viral suppression, but did improve ART adherence as measured by the EDM through week 36. Study participants included 13-24 year old youth living with HIV who failed ART therapy defined as having detectable HIV virus (HIV-1 RNA ≥200 copies/ml) within 45 days of enrollment despite having been on ART for at least 24 weeks.