Integrated gene expression and alternative splicing analysis in human and mouse models of Rett Syndrome.

The folder "Homo_sapiens" contains 8 subfolders. Each of them is an individual input Bioproject downloaded from SRA and reanalized with the same transcriptomic pipeline in order to compute:1) Differentially Alternative spliced Genes (DAS) in .tsv format;2) Differentially expressed genes in csv format;3) Gene ontology analysis over DEGs results. When the analysis has produced statistically significant results for Gene Enrichment Ontology analysis, three .csv files have been added to each folder, one for BP=Biological Process results, one for CC=Cellular Component results and one for MF=Molecular Functions results.When a Bioprojects appears more than once, it means that DEGs have been computed over diffferent varibles (e.g. Rtt vs. wt) or treated as indipendent studies when multiple source materials are present. To distinguish the studies an "_<i>0", "_</i><i>1", "</i>_2" progressive number has been added to the folder names (e.g. in PRJNA509687_0 the samples under study were iPSC derived neural cortical neurons RTT vs. Wt while in PRJNA509687_1 the samples were derived from iPSC derived neural progenitors RTT vs. Wt). To facilitate the folder navigation, a file named "parameters" has been added to each folder.4) DESeq2 inputs divided in:gene count matrices in csv formatassociated phenodata.csvThe same logic is applied to the main folder "Mus_musculus",which contains 13 subfolders with DAS and DEG results.<br><br>