Noble1998_VentricularCellModel_ModelC

This a model from the article:
Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and
IKs, and length- and tension-dependent processes.

Noble D, Varghese A, Kohl P, Noble P. Can J Cardiol
1998 Jan;14(1):123-34 9487284
,
Abstract:

The guinea-pig ventricular cell model, originally developed by Noble et al in
1991, has been greatly extended to include accumulation and depletion of calcium
in a diadic space between the sarcolemma and the sarcoplasmic reticulum where,
according to contempory understanding, the majority of calcium-induced calcium
release is triggered. The calcium in this space is also assumed to play the
major role in calcium-induced inactivation of the calcium current. Delayed
potassium current equations have been developed to include the rapid (IKr) and
slow (IKs) components of the delayed rectifier current based on the data of of
Heath and Terrar, along with data from Sanguinetti and Jurkiewicz. Length- and
tension-dependent changes in mechanical and electrophysiological processes have
been incorporated as described recently by Kohl et al. Drug receptor
interactions have started to be developed, using the sodium channel as the first
target. The new model has been tested against experimental data on action
potential clamp, and on force-interval and duration-interval relations; it has
been found to reliably reproduce experimental observations.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Noble D, Varghese A, Kohl P, Noble P. (1998) - version=1.0

The original CellML model was created by:
Penny Noble

[e-mail]
The University of Oxford
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