Transcriptomic landscape of the hippocampus in 2- and 4-month-old rTg4510 mice and wild-type littermates

The objective of this study was to compare the hippocampal transcriptomic landscape of the rTg4510 mouse model of tauopathy (Tg) at two ages (2 and 4 months) with that of wild-type (WT) littermates at the same ages, and to assess age-related changes (2 vs 4 months) within each genotype. The rTg4510 line overexpresses a repressible form of human tau carrying the P301L mutation. Tau expression is controlled by a tetracycline-responsive element (tetO) and driven by a forebrain-specific transactivator under the CaMKIIa promoter. Mice were maintained without doxycycline. In the absence of doxycycline, tau expression is induced primarily in the hippocampus and cortex, leading to progressive tau pathology (including tau hyperphosphorylation and neurofibrillary tangle formation) and associated neurodegenerative phenotypes. Transcriptomic changes in the hippocampus during early disease evolution (2 vs 4 months) are still incompletely characterized. This dataset provides bulk hippocampal RNA-seq data to support the analysis of age- and genotype-associated molecular changes in this model.