Genomic co-events significantly associated with drug response to the MEK inhibitor GSK1120212.

The top 30 significant single, double and triple genomic co-events are represented here. The frequency of the event in sensitive vs resistant lines is represented by a ratio. #DIV/0!/infinite denotes a strong association with sensitivity. Increasing association with sensitivity in cell lines is indicated by an increasing freq S/freq R ratio >1.5, and increasing association with resistance by a decreasing ratio <0.67, as shown. Top co-events where selected when they fulfilled the following 3 criteria: [1] most significant P-values (P< = 0.05), with [2] the maximum number of cell lines harboring the event, and [3] an S/R ratio that was the furthest from unity in both directions.