Transcriptomic response to calcium in normal colon organoids is impacted by colon location and sex. Transcriptomic response to calcium in normal colon organoids is impacted by colon location and sex

Here, we used bulk RNA-seq data derived from healthy colon organoids exposed to two differing calcium concentrations. Through the use of external single cell RNA-seq data, we estimate changes in cell composition and gene expression brought about by high calcium conditions and relate those effects to colorectal cancer. Overall design: Analysis of the effects of carcinogen treatment on gene expression in colon organoids