Antitumor activity of FL118 versus irinotecan in nude mice bearing human colon and head-&-neck tumor xenografts.

*Tumor size was measured daily for the first 4 weeks and then 3–4 time a week. The data shown here are the final result derived from the 60-day time point. MTGI: maximum tumor growth inhibition; TDT: tumor doubling time; PR: partial tumor response; CR: complete tumor response. Treatment was initiated 7 days after the tumor transplantation when the tumor volume was 200–250 mm3. Control mice were given vehicle solution (75% saline, 20% Tween-80 and 5% DMSO). Five mice were used in each group. All drugs were given i.p. at a weekly × 4 schedule. Data are means ± SD.