Alteraciones en la memoria de crías de ratas expuestas a Flúor durante la gestación y la lactancia

Daily exposure to fluoride (F) depends mainly on the intake of this element with drinking water. When administered during gestation and lactation, F has been associated with cognitive deficits in the offspring. However, the mechanisms underlying the neurotoxicity of F remain obscure. In the current study, we investigated the effects of oral exposure to low levels of F during the gestational and lactation periods, on the memory of adult female rat offspring. We also considered a possible underlying neurotoxic mechanism. Our results showed that this exposure reduced step-down latency in the inhibitory avoidance task, and decreased both mRNA expression of the α7 nicotinic receptor (nAChR) and catalase activity in hippocampus.
Our data indicates that low F concentrations administrated during gestation and lactation decrease the memory of 90-day-old female offspring. This suggests that the mechanism might be connected with an α7 nAChR deficit in the hippocampus, induced by oxidative stress.

氟化物（F）的日常暴露主要依赖于通过饮用水摄入该元素。在妊娠和哺乳期间使用氟化物已被与后代认知缺陷相关联。然而，氟化物神经毒性的潜在机制尚不明确。在当前研究中，我们探讨了在妊娠和哺乳期间对低水平氟化物的口服暴露对成年雌性大鼠后代记忆的影响。同时，我们也考虑了潜在的神经毒性机制。我们的结果表明，这种暴露降低了抑制回避任务中的降级潜伏期，并减少了海马体中α7烟碱型乙酰胆碱受体（nAChR）的mRNA表达和过氧化氢酶活性。我们的数据表明，在妊娠和哺乳期间给予的低浓度氟化物降低了90日龄雌性后代的记忆力。这表明该机制可能与海马体中由氧化应激引起的α7 nAChR缺乏有关。