HCMV Binds Host Cell Receptor - Endocytic Pathway

Viral attachment and penetration of Human Cytomegalovirus (HCMV) occurs either via direct HCMV fusion with the cell membrane or via endocytosis. The endocytic mechanism occurs with cell types including endothelial and epithelial cells, where the pentameric viral protein complex, gH:gL:p128:p130:p131A, facilitates entry.

人类巨细胞病毒（HCMV）的病毒附着与渗透作用，或通过HCMV与细胞膜的直接融合实现，或通过内吞作用进行。内吞作用机制涉及包括内皮细胞和上皮细胞在内的多种细胞类型，其中五聚体病毒蛋白复合物gH:gL:p128:p130:p131A促进病毒进入。