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Identification of PTBPs RNA binding sites in mouse brain

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE85165
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PTBP1 and PTBP2 are RNA-binding proteins that control RNA processings, including alternative pre-mRNA splicing. The sequential down-regulation of the two proteins is necessary for neuronal maturation. However, their binding substrates in neural tissues have not been examined. Use modified version of iCLIP-seq protocols to identify RNA elements crosslinked to either flag-PTBP1 or PTBP2 in vivo in the mouse cerebral cortex.
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2019-05-15
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