Metabolic constraints on the evolution of antibiotic resistance. Metabolic profiling of antibiotic resistant E. coli populations

To investigate the role of bacterial metabolism in constraining the evolution of antibiotic resistance, we evolved Escherichia coli growing on glycolytic or gluconeogenic carbon sources to the selective pressure of three different antibiotics. In this study we performed genome sequence analysis of 26 E. coli cell populations. Results are reported in the publication: "Metabolic constraints on the evolution of antibiotic resistance" published in Molecular Systems Biology.