HDGFR2 regulates osteogenic differentiation by balancing histone crotonoylation and acetylation modifications [Cut & Tag]

Epigenetics regulates the expression of osteogenic genes and mediates the osteogenic differentiation of MSCs. It was found that hepatoma-derived growth factor (HDGFR2) is a histone methylated reader protein, which can recognize histone methylation modification and play an important "switch" role in gene transcriptional regulation. It is unclear whether HDGFR2 is involved in bone formation studies. Our study aims to investigate the effect of HDGFR2 on osteogenic differentiation and provide evidence for BMSCs as seed cells for tissue regeneration. Overall design: Examination of histone modification in WT and HDGFR2 knockoout BMSCs