Temporal requirements of HDAC function during craniofacial development.

Embryos were assigned the following groups based on the severity of craniofacial malformations when compared to wild-type embryos;+++ wild-type, +++/− Mild malformation,++ Moderate malformation,+ Severe malformation, - Jaw elements absent or not stained.Percentages reflect proportion of embryos with alcian blue stained cartilage elements to the total number of treated embryos expressed as a percentage.