Disrupting SUMOylation potentiates transactivation function and ameliorates polyglutamine AR-mediated disease
收藏Alliance of Genome Resources2026-08-01 收录
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Our findings demonstrate beneficial effects of enhancing transactivation function of the ligand-activated polyQ AR and indicate that the SUMOylation pathway may provide new targets for therapeutic intervention. We mutated conserved lysines in the polyQ AR that are targeted by SUMO, a modification that inhibits AR transactivation function.
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